In November 2019, the High Performance Greenhouse project (HiPerGreen) was nominated for the RAAK Award 2019, as one of the best applied research projects in the Netherlands. The approach taken was the development of an autonomous robotic platform including an unmanned aerial system and a rail-based system to collect data on every plant, without the need for installing a complex and expensive infrastructure. From the onset, HiPerGreen was set up as a cross-over project, i.e. as a cooperation between three different domains: Technology, Biology, and Business. This paper discusses the challenges faced, lessons learned and critical factors in making the project into a success.