Background: Since anxiety and depressive disorders often recur, self-management competencies are crucial for
improving the long-term course of anxiety and depressive disorders. However, few relapse prevention programmes
are available that focus on improving self-management. E-health combined with personal contact with a mental
health professional in general practice might be a promising approach for relapse prevention. In this protocol, the
GET READY (Guided E-healTh for RElapse prevention in Anxiety and Depression) study will be described in which a
relapse prevention programme is developed, implemented and evaluated. The aim of the study is to determine
patients’ usage of the programme and the associated course of their symptoms, to examine barriers and facilitators
of implementation, and to assess patients’ satisfaction with the programme.
Methods: Participants are discharged from mental healthcare services, and are in complete or partial remission.
They receive access to an E-health platform, combined with regular contact with a mental health professional in
general practices. Online questionnaires will be completed at baseline and after 3, 6 and 9 months. Also, semi-structured
qualitative individual interviews and focus group interviews will be conducted with patients and mental health
Discussion: This mixed-methods observational cohort study will provide insights into the use of a relapse prevention
programme in relation to the occurrence of symptoms, as well as in its implementation and evaluation. Using the
results of this study, the relapse prevention programme can be adapted in accordance with the needs of patients and
mental health professionals. If this programme is shown to be acceptable, a randomized controlled trial may be
conducted to test its efficacy.
Trial registration: Retrospectively registered in the Netherlands Trial Register (NTR7574; 25 October 2018).